Op-brai140215 1..13
نویسندگان
چکیده
1 Division of Neurosurgery, Hospital for Sick Children, Department of Surgery, University of Toronto, Toronto, Ontario, Canada 2 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada 3 Neuroscience and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada 4 Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada 5 Department of Psychology, University of Toronto, Toronto, Ontario, Canada 6 Division of Neurology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
منابع مشابه
Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.
Matrix metalloproteinase-13 (collagenase-3), a member of the family of matrix metalloproteinases (MMPs), plays a major pathological role in the cartilage destruction of arthritis. A dramatic up-regulation of MMP-13 by inflammatory cytokines such as interleukin (IL)-1beta or by fibronectin fragments has been observed in chondrocytes. In this study, we investigated the inhibitory effects of insul...
متن کاملAnti-catabolic Effect of Op-1 (bmp-7) in Chronically Compressed Intervertebral Discs
INTRODUCTION. There are several reports on experimental animal models of disc degeneration, which have been used to assess biomechanical behavior, biochemical composition and biological changes in the intervertebral discs. Although it is difficult to distinguish normal age-related alterations in the intervertebral disc from pathological degeneration, it is well known that the nucleus pulposus (...
متن کاملInhibitory Effects of Igf-1 and Op-1 on Fibronectin Fragment and Il-1 Stimulated Mmp-13expression by Human Chondrocytes
Members of the family of matrix metalloproteinases (MMPs) are key enzymes in matrix degradation. Recently, in vitro, clinical, and transgenic studies have provided evidence that MMP-13 (collagenase-3) is a leading candidate enzyme mediating degradation of type II collagen in OA cartilage (1). A dramatic up-regulation of MMP-13 by inflammatory cytokines such as IL-1β (2) or by fibronectin fragme...
متن کاملComparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model.
STUDY DESIGN Posterolateral lumbar spine fusions in athymic rats. OBJECTIVES To compare spine fusion rates of two different osteoinductive products. SUMMARY OF BACKGROUND DATA Many osteoinductive bone graft alternatives are available. Grafton (a demineralized bone matrix [DBM]) and Osteogenic Protein-1 (OP-1, an individual recombinant bone morphogenetic protein) are two such alternatives. T...
متن کاملHigh-dose 3D-CRT in the radical and postoperative setting for prostate cancer. Analysis of survival and late rectal and urinary toxicity.
PURPOSE The aim of the study was to retrospectively compare outcome and complications of prostate cancer patients treated with a curative and postoperative intent using a pretreatment defined NCCN classification. MATERIAL AND METHODS A total of 103 patients was treated curatively (RAD) and 94 postoperatively (POST-OP). The mean age was higher in the RAD group (72.6 years; range, 56.4-85.1) th...
متن کامل